Co-Investigators: Lilly Tran, MS; Ryan Caldwell, CP
Funded by: Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD) and National Institute of Biomedical Imaging and Bioengineering (NIBIB) 5R01EB019337
Status: In Progress
This proposal aims to develop a stretchable and flexible sensor technology capable of transforming healthcare from reactive and hospital-centered to preventive, proactive, evidence-based, and person-centered. The goal is to offer ‘skin-like’ properties, to enable intimate, complete non-invasive integration with the patient. The resulting ‘epidermal’ electronic devices (Kim, Lu et al. 2011) may allow clinicians to monitor their patients, and the general public to assess, continuously, their health and wellbeing. The proposed interface monitoring system, designed to promote residual limb health in persons who wear prostheses, in physical forms that are skin-like, may demonstrate key technological and scientific advancements towards evidenced-based and person-centered prosthetic care.
The work involves collaboration across three institutions to:
- Develop ‘skin-like’ pressure, strain and temperature sensors, with wireless operation, as well as hydration and blood flow sensors that operate inside a prosthetic socket.
- Develop computational modeling and algorithms for statistical signal processing of the sensor data and pattern recognition to create a user-friendly interface for clinicians and patients.
- Apply the proposed sensor technologies and data processing and pattern recognition techniques to prosthetic clinical practice. The continuous capture, storage and transmission of sensor data are critical to the design of lower limb prosthetics for improved health and healthcare.
The proposed work will improve health by leading development of new biomedical imaging devices for early detection and prevention of health problems and assessment of health status. In addition to prosthetic care, the proposal may address an unmet need for a model system for individualized healthcare, in which continuous sensing, monitoring and assessment are performed using wireless epidermal sensors instead of traditional lab-based instrumentation.
Focus Groups Used to Gather Stakeholder Input
As a first step in ensuring the clinical relevance and usefulness of the proposed development work, we convened two focus groups, one group consisting of Certified Prosthetists and one group of lower-limb prosthesis users, to gather input on system configuration and data presentation. The focus groups were held at NUPOC on January 21 and March 16 2015, respectively. The very fruitful discussions were recorded and currently are being transcribed for further analysis.
Kim, D. H., N. Lu, R. Ma, Y. S. Kim, R. H. Kim, S. Wang, J. Wu, S. M. Won, H. Tao, A. Islam, K. J. Yu, T. I. Kim, R. Chowdhury, M. Ying, L. Xu, M. Li, H. J. Chung, H. Keum, M. McCormick, P. Liu, Y. W. Zhang, F. G. Omenetto, Y. Huang, T. Coleman and J. A. Rogers (2011). "Epidermal electronics." Science333(6044): 838-843.
NUPOC would like to acknowledge the support of Ottobock in providing two residual limb models for use in this project.
NUPOC would like to thank the prosthetists and prosthesis users who participated in our focus groups for their candid and helpful comments. We also would like to acknowledge research extern, Matthew Quigley, for his invaluable help in preparing for the focus groups. Additionally, we thank Dr. R. J. Garrick for moderating, Piper Kruse for audio recordings, and Linda India for support with catering and administration.
Tran L, Caldwell R, Quigley M, Fatone S (2018) Stakeholder Perspectives for Possible Residual Limb Monitoring System for Persons with Lower-Limb Amputation. Disability and Rehabilitation (doi: 10.1080/09638288.2018.1492634; Epub ahead of print).
Zhang Y, Webb RC, Luo H, Xue Y, Kurniawan J, Cho NH, Krishnan S, Li Y, Huang Y, and Rogers JA (2016) Theoretical and Experimental Studies of Epidermal Heat Flux Sensors for Measurements of Core Body Temperature. Adv. Healthcare Mater. 2016, 5, 119–127.
Fatone S, Huang Y, Rogers J, Coleman T (2017) Interface Monitoring System to Promote Residual Limb Health. Ignite Talk and poster at the 2017 NSF Smart and Connected Health (SCH) Principal Investigators Meeting, March 20-22, Boston, MA.
Caldwell R, Yohay J, Tran L, Chung HU, Jung I, Rogers J, Fatone S (2017) Description of a prototype residual limb monitoring system. NUPOC Biennial Symposium for Initiative ’93, March 13, Chicago, IL.
Tran L, Caldwell R, Yohay J, Chung HU, Jung I, Rogers J, Fatone S (2017) Description and demonstration of a prototype residual limb monitoring system. Midwest Chapter of the American Academy of Orthotists and Prosthetists, November 11, Chicago, IL.
Tran L, Han S, Caldwell R, Rogers J, Coleman T, Fatone S (2017) Ability of Epidermal Sensors to Measure Lower-Limb Temperature during Activity with a Prosthesis Simulator. The 43rd Academy Annual Meeting & Scientific Symposium of the American Academy of Orthotists & Prosthetists (AAOP), March 1-4, Chicago, IL.
Fatone S, Caldwell R (2016) Socket-Related Research Collaborations at Northwestern University. Scheck Fair. April 8-9, Lombard, Illinois.
Tran L, Caldwell R, Quigley M, Fatone S (2016) Stakeholder Input on a Residual Limb Monitoring System. 42nd American Academy of Orthotists and Prosthetists Annual Meeting & Scientific Symposium, March 9-11, Orlando, FL.
Tran L, Caldwell R, Quigley M, Fatone S (2016) Stakeholder Input on Development of a Residual Limb Health Monitoring System. NUPOC Biennial Symposium for the German-Speaking Travel Fellows of Initiative ’93, February 25, Chicago, Illinois.
Tran L, Caldwell R, Quigley M, Fatone S (2016) Stakeholder Input on the Development of a Residual Limb Monitoring System. 12th Annual Lewis Landsberg Research Day, April 7, Northwestern University, Chicago, IL (poster).
Tran L, Han S, Caldwell R, Rogers J, Coleman T, Fatone S (2016) Ability of epidermal sensors to measure lower limb temperature during activity with a prosthesis simulator. Midwest Chapter of the American Academy of Orthotists and Prosthetists, November 3-5, Rosemont, IL.
Fatone S, Huang Y, Coleman T, Rogers J, Banks A, Tran L, Caldwell R, Brown D, Pharr M (2015) Interface Monitoring System to Promote Residual Limb Health (poster). 2015 NSF Smart and Connected Health (SCH) Principal Investigators Workshop: Amplifying Discovery through Shared Resources and Defining and Measuring Health Impact in SCH Research, June 30-July 1, 2015, Arlington, VA.
Fatone S, Huang Y, Rogers J, Coleman T, Tran L (2015) Interface Monitoring System to Promote Residual Limb Health. Ignite Talk at the 2015 NSF Smart and Connected Health (SCH) Principal Investigators Workshop: Amplifying Discovery through Shared Resources and Defining and Measuring Health Impact in SCH Research, June 30-July 1, 2015, Arlington, VA. [Access PDF, see Section #57, pages 115-120.]
Leitner Tammy and Capitanini Lisa. Human Body Merges with Technology in 'Biohacking' Trend, NBC 5, Chicago, IL (Published Monday, Sept. 21, 2015).
Tran L, Fatone S, Caldwell R (2015) Stakeholder Input on Development of a Residual Limb Health Monitoring System. Midwest Chapter, American Academy of Orthotists and Prosthetists Annual Meeting and Scientific Session, May 27-29, Rosemont, IL.
Clark V. (March 2017) O&P Research Supports Evidence-based Care. The O&P Edge, 16(3):20-34. http://www.oandp.com/articles/2017-03_01.asp
Co-Principal Investigator, John Rogers, Joins Northwestern University
Co-Principal investigator, collaborator and innovator, John Rogers, joined Northwestern University in autumn 2016 as the Louis Simpson and Kimberly Querrey Professor of Materials Science and Engineering, Biomedical Engineering and Medicine.
Monitoring Limb Health
Signals from skin-like sensors can be wirelessly monitored